Optimal DNA & Methylation Test

Methylation and nutrition in full, plus sleep, stress, skin and fitness. The Stride DNA & Methylation Test shows how efficiently your body methylates and uses key nutrients like folate and other B vitamins, with insight into genes such as MTHFR, MTR, MAOA and COMT.

  • At-home test
Sample
Swab
Collection
At-home cheek swab, posted to the lab
Results in
10 days
Biomarkers
110
Doctor reviewed
No
Tests for
  • ADNOS3
  • BHMT
  • CBS (C699T)
  • COMT
  • DHFR
  • FUT2
  • GSS
  • MAOA
  • MAOB
  • MTHFD1
  • MTHFR (A1298C)
  • MTHFR (C677T)
  • +48 more

Test specifications

Provider
Stride
Sample type
swab
Collection method
at-home cheek swab, posted to the lab
Turnaround time
10 days
Biomarkers tested
110
At-home test
Yes
Doctor reviewed
No
Report type
genetic-report
Gender focus
Both

What's tested

60 biomarkers as listed by Stride, of 110 in total.

Methylation

  • ADNOS3
  • BHMT
  • CBS (C699T)
  • COMT
  • DHFR
  • FUT2
  • GSS
  • MAOA
  • MAOB
  • MTHFD1
  • MTHFR (A1298C)
  • MTHFR (C677T)
  • MTR
  • MTRR
  • PEMT
  • SOD2ORA2A
  • TCN2
  • VDR

Nutrition

  • ACE
  • ADH1C
  • ADRB2
  • AGT
  • ALDOB
  • APOA2
  • APOA5
  • APOC3
  • APOE
  • BCMO1
  • BCO1
  • CAT
  • CBS
  • CETP
  • CLOCK
  • CYP1A2
  • CYP4F2
  • EPHX1
  • FABP2
  • FTO
  • GPX1
  • GSTT1
  • HFE
  • HLA DQ2/DQ8
  • IL6
  • INSIG
  • LCT/MCM6
  • LEPR
  • LIPC
  • LPL
  • MC4R
  • NBPF3
  • PLIN
  • PPARG
  • SLC23A1
  • SOD2
  • TCF7L2
  • TF
  • TFR2
  • TMPRSS6
  • TNF
  • ZPR1

About this test

About this test

Stride's Optimal DNA & Methylation Test is designed for users who want a deeper view of how their methylation pathways are likely to function based on genetics. Rather than stopping at a simple MTHFR-style result, it expands into wider nutrigenetic and lifestyle-relevant context.

Who is this test for?

This test is best for users who want a broad methylation genetics overview, especially those interested in nutrient processing, energy, detoxification, recovery, and longer-term optimisation rather than a narrow yes-or-no gene screen.

How the test works

You complete an at-home DNA collection kit and the sample is analysed to generate methylation-focused genetic insights. Results are translated into a user-facing report designed to make complex pathway information more actionable.

Pros & cons

Pros

  • Broad methylation-oriented genetic coverage
  • Goes beyond narrow single-gene screening
  • At-home DNA workflow is convenient
  • Strong fit for users who want practical methylation interpretation

Cons

  • More expensive than narrow MTHFR-only options
  • May provide more detail than casual users need
  • Genetic insight still benefits from contextual interpretation

Our editorial score

ProjectScreen Score Best for broad methylation genetics
Editorial confidence: 8.4/10

Score breakdown

  • Clarity and UX 8.2/10

    Clear positioning for users who want guided methylation insight.

  • Clinical Depth 9.2/10

    Broad pathway-oriented methylation genetics makes this stronger than narrow single-gene tests.

  • Collection Convenience 8.8/10

    At-home DNA collection is convenient and low friction.

  • Price Value 8.4/10

    Strong value if you want a more complete methylation genetics view.

  • Results and Follow-up 9.0/10

    Designed to support practical next steps rather than raw data only.

  • Trust Signals 8.8/10

    Strong positioning and detailed public explanation of the test scope.

Compare with similar tests

This test belongs to our DNA and methylation test comparison group. See how it stacks up against equivalent tests from other providers.

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Methylation Stack

Optimal DNA & methylation test including 46 reports, plus 3 months' supply of MS-01, our methylated B vitamin complex. Unlock your methylation blueprint + daily support.

  • At-home test
8.6 / 10 Best for testing plus support bundle

Advanced DNA & Methylation Test

The five cycles in full, plus 24 reports on how you process food. The Stride DNA & Methylation Test shows how efficiently your body methylates and uses key nutrients like folate and other B vitamins, with insight into genes such as MTHFR, MTR, MAOA and COMT.

  • At-home test

Core DNA & Methylation Test

All five methylation cycles. The Stride DNA & Methylation Test shows how efficiently your body methylates and uses key nutrients like folate and other B vitamins, with insight into genes such as MTHFR, MTR, MAOA and COMT.

  • At-home test